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2β-Propanoyl-3β-(2-naphthyl)-tropane

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2β-Propanoyl-3β-(2-naphthyl)-tropane
Systematic (IUPAC) name
2β-Propanoyl-3β-(2-naphthyl)-tropane
Clinical data
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Bioavailability high
Metabolism slow
Identifiers
ATC code  ?
Chemical data
Formula C21H25NO 
Mol. mass 307.43

2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 is a cocaine analogue. It is claimed to be several hundred times more potent than cocaine at being serotonin-norepinephrine-dopamine reuptake inhibitor.[1]

As can be seen on pubmed, these acyl substituted phenyltropanes are highly potent MAT inhibitors and also have a very long half-life, spanning perhaps at least a few days.[2][3]

See also

References

  1. ^ U.S. Patent 6,008,227
  2. ^ Bennett; Wichems, C. H.; Hollingsworth, C. K.; Davies, H. M.; Thornley, C.; Sexton, T.; Childers, S. R. (1995). "Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain". The Journal of pharmacology and experimental therapeutics 272 (3): 1176–1186. PMID 7891330.  edit
  3. ^ Daunais; Hart, S. L.; Smith, H. R.; Letchworth, S. R.; Davies, H. M.; Sexton, T.; Bennett, B. A.; Childers, S. R. et al. (1998). "Long-acting blockade of biogenic amine transporters in rat brain by administration of the potent novel tropane 2beta-propanoyl-3beta-(2-Naphthyl)-tropane". The Journal of pharmacology and experimental therapeutics 285 (3): 1246–1254. PMID 9618429.  edit

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