AK3L1

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AK4
Protein AK3L1 PDB 2ar7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AK4, AK 4, AK3, AK3L1, AK3L2, adenylate kinase 4
External IDs MGI: 87979 HomoloGene: 100316 GeneCards: AK4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_203464
NM_001005353
NM_013410

NM_001177602
NM_001177604
NM_001177605
NM_009647

RefSeq (protein)

NP_001005353.1
NP_037542.1
NP_982289.1

NP_001171073.1
NP_001171075.1
NP_001171076.1
NP_033777.1

Location (UCSC) Chr 1: 65.15 – 65.23 Mb Chr 4: 101.42 – 101.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Adenylate kinase isoenzyme 4, mitochondrial is an enzyme that in humans is encoded by the AK3L1 gene.[3][4]

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1.[4] Expression of AK4 may regulate global cellular ATP levels and modulate the AMPK signaling pathway.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Noma T, Fujisawa K, Yamashiro Y, Shinohara M, Nakazawa A, Gondo T, Ishihara T, Yoshinobu K (Aug 2001). "Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix". Biochem J. 358 (Pt 1): 225–32. doi:10.1042/0264-6021:3580225. PMC 1222051Freely accessible. PMID 11485571. 
  4. ^ a b "Entrez Gene: AK3L1 adenylate kinase 3-like 1". 
  5. ^ Lanning, NJ; Looyenga, BD; Kauffman, AL; Niemi, NM; Sudderth, J; DeBerardinis, RJ; MacKeigan, JP (May 8, 2014). "A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels". Cell Reports. 7 (3): 907–917. doi:10.1016/j.celrep.2014.03.065. PMID 24767988. 

Further reading[edit]