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In human physiology, base deficit refers to a deficit in the total serum concentration of bicarbonate. It can be indicative of metabolic acidosis (such as in a case of lactic acidosis due to anaerobic metabolism) or compensatory respiratory alkalosis.
A base deficit usually translates to an excess of acid. It refers to the amount of base needed to titrate a serum pH back to normal when the contribution of respiratory factors is taken out of the equation.
Base deficit is oftentimes reported as a negative base excess. Therefore a base excess of -5 is a base deficit of 5.
- ^ Davis, J W; R C Mackersie, T L Holbrook, D B Hoyt (1991-08). "Base deficit as an indicator of significant abdominal injury". Annals of Emergency Medicine 20 (8): 842–4. doi:10.1016/S0196-0644(05)81423-4. ISSN 0196-0644. PMID 1854065. http://www.ncbi.nlm.nih.gov/pubmed/1854065. Retrieved 2009-02-08.
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