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Clebopride

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Clebopride
Systematic (IUPAC) name
4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-
2-methoxybenzamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 55905-53-8 YesY
ATC code A03FA06
PubChem CID 2780
ChemSpider 2678 YesY
UNII I0A84520Y9 YesY
KEGG D03534 YesY
ChEMBL CHEMBL325109 YesY
Chemical data
Formula C20H24ClN3O2 
Mol. mass 373.876 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.[1]


References

  1. ^ Cuena Boy R, Maciá Martínez MA (1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]" (in Spanish). Atencion Primaria 21 (5): 289–95. PMID 9608114.  Free full text



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