Desmethoxyfallypride

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Desmethoxyfallypride (18F)
Desmethoxyfallypride 18F.svg
Systematic (IUPAC) name
5-(3-18F-fluoropropyl)-2-methoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide
Clinical data
Pregnancy
category
  • N/A
Legal status
  • Research compound
Identifiers
ATC code None
PubChem CID: 9543408
ChemSpider 8580101
Synonyms DMFP (18F)
Chemical data
Formula C19H27FN2O2
Molecular mass 333.430818 g/mol

Desmethoxyfallypride is a moderate affinity dopamine D2 receptor/D3 receptor antagonist used in medical research, usually in the form of the radiopharmaceuticals desmethoxyfallypride or DMFP(18F)[1][2] and has been used in human studies[3][4] as a positron emission tomography (PET) radiotracer.

References[edit]

  1. ^ Mukherjee, J; Yang, Z. Y.; Brown, T; Roemer, J; Cooper, M (1996). "18F-desmethoxyfallypride: A fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors". Life Sciences 59 (8): 669–78. doi:10.1016/0024-3205(96)00348-7. PMID 8761017. 
  2. ^ Leung, K (2004). "(S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-18Ffluoropropyl)-2-methoxybenzamide". PMID 20641474. 
  3. ^ Gründer, G; Siessmeier, T; Piel, M; Vernaleken, I; Buchholz, H. G.; Zhou, Y; Hiemke, C; Wong, D. F.; Rösch, F; Bartenstein, P (2003). "Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride". Journal of nuclear medicine : official publication, Society of Nuclear Medicine 44 (1): 109–16. PMID 12515884. 
  4. ^ Siessmeier, T; Zhou, Y; Buchholz, H. G.; Landvogt, C; Vernaleken, I; Piel, M; Schirrmacher, R; Rösch, F; Schreckenberger, M; Wong, D. F.; Cumming, P; Gründer, G; Bartenstein, P (2005). "Parametric mapping of binding in human brain of D2 receptor ligands of different affinities". Journal of nuclear medicine : official publication, Society of Nuclear Medicine 46 (6): 964–72. PMID 15937307. 

External links[edit]