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Doxanthrine

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Doxanthrine
Systematic (IUPAC) name
(6aS,12bR)-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline-2,3-diol
Identifiers
ATC code None
PubChem CID 15981509
Chemical data
Formula C16H15NO3 
Mol. mass 269.295 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Doxanthrine is a synthetic compound which is a potent and selective full agonist for the dopamine D1 receptor.[1][2]

References

  1. ^ Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE (November 2006). "trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist". Journal of Medicinal Chemistry 49 (23): 6848–57. doi:10.1021/jm0604979. PMID 17154515. 
  2. ^ Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ, McCorvy JD, Chester JA, Nichols DE, Watts VJ (February 2009). "Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology 19 (2): 138–46. doi:10.1016/j.euroneuro.2008.10.002. PMID 19028082. 

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