Etafedrine

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Etafedrine
Etafedrine Structural Formulae (1R,2S).png
Systematic (IUPAC) name
(1R,2S)-N-ethyl-N-methyl-2-amino-1-phenylpropan-1-ol
Clinical data
Identifiers
7681-79-0 YesY
None
PubChem CID 10734
ChemSpider 85308 N
UNII 2Y6VQU63E8 YesY
Chemical data
Formula C12H19NO
193.285 g/mol
 N (what is this?)  (verify)

Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has the brand name Nethaprin. It was previously commercially available as both the free base and as the hydrochloride salt from Sanofi-Aventis but is now no longer marketed.

Pharmacology[edit]

Unlike ephedrine and tyramine, etafedrine does not induce the release of epinephrine or norepinephrine and instead acts as a selective β-adrenergic receptor agonist, thereby mediating its bronchodilator effects.[1]

Synthesis[edit]

Etafedrine synthesis:[2][3]

See also[edit]

References[edit]

  1. ^ Lindmar R, Löffelholz K, Stieh-Koch U (1985). "On the mechanism of bronchodilatation by etafedrine". Arzneimittel-Forschung 35 (3): 602–4. PMID 4039586. 
  2. ^ doi:10.1002/cber.19300630104
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  3. ^ Ueda et al., Pharm. Bull. 3, 465 (1955).