Fallypride

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Fallypride (18F)
Fallypride F18.svg
Systematic (IUPAC) name
5-(3-18F-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide
Clinical data
Pregnancy cat. N/A
Legal status Research compound
Identifiers
ATC code None
PubChem CID 10021692
Chemical data
Formula C20H29FN2O3 
Mol. mass 364.454263 g/mol

Fallypride is a high affinity dopamine D2/D3 receptor antagonist used in medical research,[1] usually in the form of fallypride (18F) as a positron emission tomography (PET) radiotracer in human studies.[2][3]

References[edit]

  1. ^ Mukherjee, J; Yang, Z. Y.; Das, M. K.; Brown, T (1995). "Fluorinated benzamide neuroleptics--III. Development of (S)-N-(1-allyl-2-pyrrolidinyl)methyl-5-(3-18Ffluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer". Nuclear medicine and biology 22 (3): 283–96. PMID 7627142.  edit
  2. ^ Mukherjee, J; Christian, B. T.; Dunigan, K. A.; Shi, B; Narayanan, T. K.; Satter, M; Mantil, J (2002). "Brain imaging of 18F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors". Synapse 46 (3): 170–88. doi:10.1002/syn.10128. PMID 12325044.  edit
  3. ^ Rieck, R. W.; Ansari, M. S.; Whetsell Jr, W. O.; Deutch, A. Y.; Kessler, R. M. (2004). "Distribution of dopamine D2-like receptors in the human thalamus: Autoradiographic and PET studies". Neuropsychopharmacology 29 (2): 362–72. doi:10.1038/sj.npp.1300336. PMID 14627996.  edit


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