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Skeletal formula of fluotracen
Ball-and-stick model of the fluotracen molecule
Systematic (IUPAC) name
Clinical data
  • Uncontrolled
57363-14-1 (HCl)
PubChem CID 42291
ChemSpider 38565
UNII 3026WKR55S YesY
Chemical data
Formula C21H24F3N
347.42 g/mol

Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity.[1][2][3] This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis.[1] It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder (i.e., negative symptoms), and usual antipsychotics often worsen such symptoms.[1] In any case, however, fluotracen was never marketed.[3]

See also[edit]


  1. ^ a b c Annual Reports in Medicinal Chemistry: v. 14. Academic Press Inc.,U.S. 1979. ISBN 0-12-040514-8. 
  2. ^ Fowler PJ, Zirkle CL, Macko E et al. (1977). "Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals". Arzneimittel-Forschung 27 (8): 1589–95. PMID 410422. 
  3. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.