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GSK-789,472

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GSK-789,472
Systematic (IUPAC) name
4,5-dihydro-1-phenyl-3-(piperidin-2-yl)methylimidazol-2(1H)one
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
ATC code None
Chemical data
Formula C15H21N3O 
Mol. mass 259.168 g/mol
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

GSK-789,472 is a drug which acts as both a potent and selective partial agonist at the dopamine receptor D2, as well as an antagonist at the related D3 subtype, but with good selectivity over D4 and other unrelated receptors.[1]

References

  1. ^ Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (March 2010). "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters 20 (6): 2013–6. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647. 



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