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16e chemical structure.png
Systematic (IUPAC) name
Clinical data
Legal status ?
CAS number 807342-16-1 N
ATC code ?
PubChem CID 11291199
ChemSpider 9466185 N
Chemical data
Formula C18H27ClN2OS 
Mol. mass 354.937 g/mol
 N (what is this?)  (verify)

JZ-IV-10 is a piperidine derivative related to nocaine which is a highly potent serotonin–norepinephrine–dopamine reuptake inhibitor (also called SNDRI, or triple reuptake inhibitor).[1] The eugeroic modafinil was used as a lead to fuel this compound's discovery.[2][3]


  1. ^ WO 2005041875 
  2. ^ Zhou, J.; He, R.; Johnson, K. M.; Ye, Y.; Kozikowski, A. P. (2004). "Piperidine-Based Nocaine/Modafinil Hybrid Ligands as Highly Potent Monoamine Transporter Inhibitors: Efficient Drug Discovery by Rational Lead Hybridization" (pdf). Journal of Medicinal Chemistry 47 (24): 5821–5824. doi:10.1021/jm040117o. PMC 1395211. PMID 15537337. 
  3. ^ He, R.; Kurome, T.; Giberson, K. M.; Johnson, K. M.; Kozikowski, A. P. (2005). "Further Structure-Activity Relationship Studies of Piperidine-Based Monoamine Transporter Inhibitors: Effects of Piperidine Ring Stereochemistry on Potency. Identification of Norepinephrine Transporter Selective Ligands and Broad-Spectrum Transporter Inhibitors". Journal of Medicinal Chemistry 48 (25): 7970–7979. doi:10.1021/jm050694s. PMID 16335921.