Levomethamphetamine affects the central nervous system, although its effects are weaker and somewhat shorter than those of dextromethamphetamine, so it is not thought to possess the same addiction potential as that of racemicmethamphetamine or dextromethamphetamine. Among its few physiological effects are the vasoconstriction that makes it useful for nasal decongestion. The elimination half-life of levomethamphetamine is between 13.3 and 15 hours, whereas dextromethamphetamine has a half-life of about 10.5 hours.
In a study of psychoactive effects of levomethamphetamine, the intravenous administration of 0.5 mg/kg (but not 0.25 mg/kg) in methamphetamine abusers produced scores of "drug liking" similar to racemic methamphetamine, but the effects were shorter lived. The study did not test the oral administration of levomethamphetamine. Currently there are no studies demonstrating "drug liking" scores of oral levomethamphetamine that are similar to racemic methamphetamine or dextromethamphetamine in either methamphetamine abusers and legitimate users.
^Melega, WP; Cho, AK; Schmitz, D; Kuczenski, R; Segal, DS (February 1999). "l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine". The Journal of pharmacology and experimental therapeutics288 (2): 752–8. PMID9918585.
^ abMendelson, J; Uemura, N; Harris, D; Nath, RP; Fernandez, E; Jacob P, 3rd; Everhart, ET; Jones, RT (October 2006). "Human pharmacology of the methamphetamine stereoisomers". Clinical pharmacology and therapeutics80 (4): 403–20. doi:10.1016/j.clpt.2006.06.013. PMID17015058.Cite uses deprecated parameters (help)
^Kuczenski, R; Segal, DS; Cho, AK; Melega, W (February 1995). "Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine". The Journal of neuroscience : the official journal of the Society for Neuroscience15 (2): 1308–17. PMID7869099.
^Nonprescription Products to Avoid With Hypertension by W. Steven Pray, PhD, DPh, Bernhardt Professor, Nonprescription Products and Devices, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, Oklahoma US Pharm. 2010;35(2):12-15. Posted 19 February 2010. Accessed via internet 26 May 2010. This new article incorporates the information formerly drawn from the article cited at the corresponding point in a previous version of this page, which article's former URL now forms a dead link.
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