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Norpholedrine

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para-hydroxyamphetamine
Systematic (IUPAC) name
4-(2-aminopropyl)phenol
Identifiers
CAS number 206-181-4
ATC code  ?
PubChem CID 9377
DrugBank nil
ChEMBL CHEMBL1546
Synonyms 4-hydroxyamphetamine, p-hydroxyamphetamine, alpha-methyltryamine
Chemical data
Formula C9H13NO 
Mol. mass 151.206
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule II (US)
Routes Topical (Ocular)

para-Hydroxyamphetamine (PHA), also known as Norpholedrine (Oxamphetamine, Paredrine), 4-hydroxyamphetamine (4-HA), and α-methyltyramine (α-Me-TRA), is a sympathomimetic drug, that is, a drug that stimulates the sympathetic nervous system. When used in eye drops, it dilates the pupil. Norpholedrine is sold in combination with tropicamide under the brand name Paremyd. It occurs as a metabolite of amphetamine.

Once thought to be a human invention, norpholedrine is now known to occur as an alkaloid in plants including Acacia berlandieri.[1]

Contents

Night vision

In 1944, the US Naval Submarine Medical Research Laboratory researched the use of Paredrine to improve adaptation to night vision in submarine personnel. A significant improvement in adaptation was shown in the 17 subjects they tested.[2]

See also

References

  1. ^ Shulgin, Alexander (September 26, 2001). "Ask Dr. Shulgin Online: Acacias and Natural Amphetamine". Center for Cognitive Liberty & Ethics. http://www.cognitiveliberty.org/shulgin/adsarchive/acacia.htm. Retrieved 2010-02-18. 
  2. ^ Verplanck, WS (1944). "The effects of paregrine on night vision performance.". US Naval Submarine Medical Research Laboratory Technical Report 42. http://archive.rubicon-foundation.org/8242. Retrieved 2010-02-18. 

External links



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