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Percocet

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Percocet
Combination of
Oxycodone Opioid Analgesic
Acetaminophen Anilide Analgesic
Identifiers
CAS number 330988-72-2
ATC code  ?
ChemSpider 4881971
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat. C
Legal status Schedule II (US)
Routes Oral

Percocet is Endo Pharmaceuticals' North American brand name for oxycodone/acetaminophen blend tablets. The blend tablet is a narcotic pain reliever used to treat moderate to severe acute (short-term) pain. [1]

Contents

History

The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.[2]

Formulation

As of March 2006, Endo Pharmaceuticals produces Percocet in following dosages.[3] Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:[3]

  • 2.5mg Oxycodone Hydrochloride/325mg Acetaminophen: pink oval tablet, maximum daily dose 12 tablets
  • 5mg Oxycodone Hydrochloride/325mg Acetaminophen: blue round tablet, maximum daily dose 12 tablets
  • 7.5mg Oxycodone Hydrochloride/325mg Acetaminophen: peach oval tablet, maximum daily dose 8 tablets
  • 7.5mg Oxycodone Hydrochloride/500mg Acetaminophen: peach capsule-shaped tablet, maximum daily dose 8 tablets
  • 10mg Oxycodone Hydrochloride/325mg Acetaminophen: white oblong tablet, imprint code L484, maximum daily dose 6 tablets
  • 10mg Oxycodone Hydrochloride/650mg Acetaminophen: yellow oval tablet, maximum daily dose 6 tablets

For the 2.5mg Oxycodone HCL tablet, the usual dose is 1-2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.[3]

Use in pain management

This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than morphine. It is very useful to give to someone who is experiencing acute severe pain that is not chronic nor breakthrough.[citation needed].

Implicated in deaths

On June 30, 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[4] be removed from the market because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to acetaminophen overdose and associated liver damage.[5]

In December 2009, the Canadian Medical Association Journal reported a study finding a 5-fold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.[6]

References

External links

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