Sunifiram

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Sunifiram
Sunifiram.svg
Legal status
Legal status
  • US: Not FDA approved; unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C14H18N2O2
Molar mass 246.304 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Sunifiram (DM-235) is a piperazine derived research chemical which has anti-amnesiac effects in animal studies with significantly higher potency than piracetam.[1] Sunifiram is closely related to, and derived from, unifiram. The anti-amnesiac effect of sunifiram and unifiram has been shown to involve AMPA-receptor activation.[2]

As of 2017 it had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world.[1]

References[edit]

  1. ^ a b Gualtieri F (2016). "Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings". Journal of Enzyme Inhibition and Medicinal Chemistry. 31 (2): 187–94. doi:10.3109/14756366.2015.1021252. PMID 25831025. 
  2. ^ Galeotti, N.; Ghelardini, C.; Pittaluga, A.; Pugliese, A.; Bartolini, A.; Manetti, D.; Romanelli, M.; Gualtieri, F. (2003). "AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)". Naunyn-Schmiedeberg's archives of pharmacology. 368 (6): 538–545. doi:10.1007/s00210-003-0812-6. PMID 14600801.