Wakefulness-promoting agent

From Wikipedia, the free encyclopedia

Jump to: navigation, search

A wakefulness-promoting agent (or wakefulness-promoting drug), also known as a eugeroic (originally "eugrégorique" or "eugregoric"),[1] is a type of drug which specifically improves wakefulness and alertness.[2][3] They are used mainly in the treatment of sleeping disorders, excessive daytime sleepiness and narcolepsy.[2][3] Wakefulness-promoting agents are said to have a low or very low addictive potential.[2][3]

The prototypical eugeroic is modafinil, and other drugs include adrafinil and armodafinil. Modafinil and armodafinil have been found to act as selective, weak, atypical dopamine reuptake inhibitors.[2][3] Adrafinil is a prodrug of modafinil, and hence also acts in this way.

Examples[edit]

The chemical structure of modafinil, the prototypical drug of this class.

Marketed[edit]

Discontinued[edit]

Never marketed[edit]

See also[edit]

Categories[edit]


References[edit]

  1. ^ Milgram, Norton W.; Callahan, Heather; Siwak, Christina (2006). "Adrafinil: A Novel Vigilance Promoting Agent". CNS Drug Reviews. 5 (3): 193–212. doi:10.1111/j.1527-3458.1999.tb00100.x. ISSN 1080-563X. 
  2. ^ a b c d "Provigil: Prescribing information" (PDF). United States Food and Drug Administration. Cephalon, Inc. January 2015. Retrieved 16 August 2015. 
  3. ^ a b c d "Nuvigil: Prescribing information" (PDF). United States Food and Drug Administration. Cephalon, Inc. April 2015. Retrieved 16 August 2015. 
  4. ^ Edgar, Christopher J.; Pace-Schott, Edward F.; Wesnes, Keith A. (18 May 2017). "Approaches to Measuring the Effects of Wake-Promoting Drugs: A Focus on Cognitive Function". Human psychopharmacology. 24 (5): 371–389. doi:10.1002/hup.1034. ISSN 0885-6222. Retrieved 18 May 2017. 
  5. ^ "To improve chronic pain, get more sleep (coffee helps too)". www.sciencedaily.com. Retrieved 18 May 2017.